A plane crash has been reported near Muhammad Ali International Airport in Louisville.
Multiple agencies are on the scene after a plane crash near Fern Valley Road and Grade Lane, just south of Louisville Muhammad Ali International Airport.

Preliminary reports indicate a major explosion followed by a large fire near Muhammad Ali International Airport in Louisville, Kentucky. Early information suggests the incident may have involved a cargo aircraft operated by UPS Airlines.
All flights operations to Louisville International Airport are halted until further notice.
A large plume of smoke was visible around 5:30 p.m., and police have confirmed injuries at the scene.
UPDATE #1
Several sources confirm the plane involved in the crash is a 34-year-old UPS MD-11 (registration N259UP) which took off from Louisville to Honolulu as flight 5X2976.

UPDATE #2
Aerial footage of the crash site.
UPDATE #3
FAA confirms UPS Flight 5X2976 crashed while taking off from Louisville International Airport in Kentucky.
UPDATE #4
Livestream from helicopter.
UPDATE #5
New footage shows the left side of UPS MD-11 on fire during takeoff from runway 17R.
UPDATE #6
3 crew members were on board and multiple buildings were destroyed.
UPDATE #7
One of the there engines separated (very probably the left one).

