Ryanair will open a new base at London Southend, from April 2019, with three based aircraft at the airport.
The carrier said it represented an investment of $300 million.
The low-cost airline will operate and 13 new routes to eight countries, including Alicante, Barcelona Reus, Bilbao, Brest, Corfu, Cluj, Dublin, Faro, Kosice, Malaga, Milan Bergamo, Palma and Venice.
Ryanair hopes the move will deliver one million guests annually to London Southend Airport.